Chirayata is anti-infective (sannipata-jvarahara, krimi-pranut, asra-nut). It promotes resolution of inflammation (shotha-pranut) and wound healing (vrana-pranut). It shows significant antimicrobial activities against Gram-positive, Gram-negative and fungi. In another study, it showed significant activity against bacteria and fungi. The activity may be indicative of the presence of broad spectrum antibiotic compounds. Antimicrobial agents can damage pathogens in several ways. The major modes of actions are interference with cell wall synthesis, inhibition of protein synthesis, interference with nucleic acid synthesis, and inhibition of a metabolic pathway.
Ativisha is appetizer (deepana), digestive (pachana), anti-hemorrhoidal (arshoghna), anti-diarrheal (atisar-hara), anti-infective (jvara-apaha), anti-helminthic (krimi-hara), anti-toxic (ama-vishahara, visha-vinashini) and astringent (sangrahak). It is widely used for the management of dyspepsia (ajirna), infective diarrhea (jvara-atisara), hemorrhoids (arsha), and helminthiasis (krimi-roga). Several alkaloids present in its root like, 6-dehydroacetyl-sepaconitine, 13-hydroxylappaconitine, lycoctonine, delphatine and lappaconitine exhibit significant antibacterial activity. Ativisha is also known as Aconitum heterophyllum.
Sulphur (Gandhak) is vital for hair and skin health. It is largely present in non-veg foods like meat, fish, and egg. In addition, it is present in milk, legumes, garlic, onion, turnip, cabbage, seaweed, and some nuts. People eating less of these foods are quite likely to develop Sulphur deficiency resulting in hair loss and reduced skin glow. This calls for the need to supplement Sulphur in the form of medicines. Gandhak helps regeneration of tissues (rasayana) and helps restore natural hair color (kesha-ranjana).
Like many other tissues and organs zinc (Yashad) is vital for the health and well-being of the hair and skin. Yashad helps regeneration of tissues (dhatu-kshaya-hara) and modulates immunity (rasapinda-vikriti-nashaka).